Lack of alpha2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions.

@article{Kanno2006LackOA,
  title={Lack of alpha2-antiplasmin improves cutaneous wound healing via over-released vascular endothelial growth factor-induced angiogenesis in wound lesions.},
  author={Yosuke Kanno and Kouseki Hirade and Akira Ishisaki and Keiichi Nakajima and Hirotaka Suga and Takeshi Into and Kenji Matsushita and Kiyotaka Okada and Osamu Matsuo and Hiroyuki Matsuno},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2006},
  volume={4 7},
  pages={1602-10}
}
BACKGROUND The fibrinolytic system is supposed to play an important role in the degradation of extracellular matrices for physiological and pathological tissue remodeling; however, the detailed mechanism regarding how this system affects cutaneous wound healing remains to be clarified. METHODS AND RESULTS We performed experimental cutaneous wounding in mice with a deficiency of alpha(2)-antiplasmin (alpha(2)AP), which is a potent and specific plasmin inhibitor. We found that an accelerated… CONTINUE READING

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