Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.

@article{Kroboth2007LackOA,
  title={Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability.},
  author={Karin Kroboth and Ian Paterson Newton and Katsuhiro Kita and Dina Dikovskaya and J{\"u}rg Zumbrunn and Clare M. Waterman-Storer and Inke S. N{\"a}thke},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 3},
  pages={
          910-8
        }
}
Most sporadic colorectal tumors carry truncation mutations in the adenomatous polyposis coli (APC) gene. The APC protein is involved in many processes that govern gut tissue. In addition to its involvement in the regulation of beta-catenin, APC is a cytoskeletal regulator with direct and indirect effects on microtubules. Cancer-related truncation mutations lack direct and indirect binding sites for microtubules in APC, suggesting that loss of this function contributes to defects in APC-mutant… CONTINUE READING

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