Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression

@inproceedings{Bourdenx2015LackOA,
  title={Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression},
  author={Mathieu Bourdenx and Sandra Dovero and Michel Engeln and Simone Bido and Matthieu F. Bastide and Nathalie Dutheil and Isabel Vollenweider and Laetitia Baud and Camille L Piron and Virginie Grouthier and Thomas Boraud and Gr{\'e}gory Porras and Qin Li and Veerle Baekelandt and Dieter K Scheller and Anne Michel and Pierre-Olivier Fernagut and François Georges and Gr{\'e}goire Courtine and Erwan B{\'e}zard and Benjamin Dehay},
  booktitle={Acta neuropathologica communications},
  year={2015}
}
INTRODUCTION Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. α-synuclein (α-syn) is a major constituent of Lewy bodies, and the first disease-causing protein characterized in PD. Several α-syn-based animal models of PD have been developed to investigate the pathophysiology of PD, but none of them recapitulate the full picture of the disease. Ageing is the… CONTINUE READING