Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells.

@article{Bruggeman1984LackOA,
  title={Lack of activity of the bacterial mutagen emodin in HGPRT and SCE assay with V79 Chinese hamster cells.},
  author={I. Bruggeman and J. V. D. van der Hoeven},
  journal={Mutation research},
  year={1984},
  volume={138 2-3},
  pages={
          219-24
        }
}
Genotoxicity of emodin was studied in the Salmonella/microsome assay, the sister-chromatid exchange (SCE) assay and the hypoxanthine-guanine-phosphoribosyltransferase (HGPRT) forward mutation assay with V79 Chinese hamster cells. In the Salmonella/microsome assay, emodin was found to be positive in TA97, TA100 and TA1537 in the presence of liver homogenate. In TA1537 a weak direct mutagenicity was also observed. In both mammalian test systems, no genotoxicity was found either with or without… Expand
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