Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people.

@article{Sullivan2011LackOA,
  title={Lack of a relationship between plasma PCSK9 concentrations and hepatic lipoprotein kinetics in obese people.},
  author={Shelby Sullivan and Elisa Fabbrini and Jay D. Horton and Kevin M. Korenblat and Bruce W. Patterson and S. Klein},
  journal={Translational research : the journal of laboratory and clinical medicine},
  year={2011},
  volume={158 5},
  pages={302-6}
}
Obesity is associated with unfavorable alterations in plasma lipid concentrations. Data obtained from studies in cultured cells and rodent models show that Protein Convertase Subtilisn/Kexin 9 (PCSK9), a secreted protein that leads to degradation of LDL receptors in the liver, is an important regulator of plasma LDL cholesterol concentrations. Recent evidence suggests that PCSK9 may also regulate the very low density lipoprotein (VLDL) receptor expression and VLDL-triglyceride (TG) metabolism… CONTINUE READING