Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury

@inproceedings{West2009LackOX,
  title={Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury},
  author={Timothy D. West and Madeliene Atzeva Stump and Gregory A. Lodygensky and Jeff J Neil and Mohanish Deshmukh and David M Holtzman},
  booktitle={ASN neuro},
  year={2009}
}
Neurological deficits caused by H-I (hypoxia-ischaemia) to the perinatal brain are often severely debilitating and lead to motor impairment, intellectual disability and seizures. Perinatal brain injury is distinct from adult brain injury in that the developing brain is undergoing the normal process of neuronal elimination by apoptotic cell death and thus the apoptotic machinery is more easily engaged and activated in response to injury. Thus cell death in response to neonatal H-I brain injury… CONTINUE READING

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