Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma.

@article{Himoudi2012LackOT,
  title={Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma.},
  author={Nourredine Himoudi and Ruth C Wallace and Kathryn L. Parsley and Kimberly Gilmour and A-U Barrie and Katherine B Howe and Ruifen Dong and Neil J Sebire and Arkadiusz Michalski and Adrian J. Thrasher and Jeffrey Eastham Anderson},
  journal={Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico},
  year={2012},
  volume={14 4},
  pages={271-9}
}
BACKGROUND Immunotherapy using autologous dendritic cell (DC) vaccination has not been systematically evaluated in osteosarcoma. We therefore conducted a phase I trial to assess feasibility, safety and tumour-specific immune responses in patients with relapsed disease. PATIENTS AND METHODS Of 13 recruited patients with relapsed osteosarcoma, 12 received 3 weekly vaccines of autologous DCs matured with autologous tumour lysate and keyhole limpet haemocyanin (KLH), to a maximum of 6… CONTINUE READING
6 Extracted Citations
20 Extracted References
Similar Papers

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 20 references

Prostaglandin E 2 enhances Th 17 responses via modulation of IL17 and IFNgamma production by memory CD 4 + T cells

  • G Napolitani, EV Acosta-Rodriguez, A Lanzavec-chia
  • Eur J Immunol
  • 2009

Similar Papers

Loading similar papers…