Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages

@inproceedings{Jiang2017LackOS,
  title={Lack of SOCS3 increases LPS-induced murine acute lung injury through modulation of Ly6C(+) macrophages},
  author={Zhilong Jiang and Zhihong Chen and Liyang Li and Wenjun Zhou and Liang Zhu},
  booktitle={Respiratory research},
  year={2017}
}
BACKGROUND SOCS3 (suppressor of cytokine signaling 3) is a negative regulator of JAK/STAT3 signaling pathway and participates in the regulation of lung inflammation in a mouse model with acute lung injury (ALI). However, it is not well understood how SOCS3 regulates lung inflammation in the ALI mouse model. METHOD In the present study, we investigated the effects of SOCS3 on modulation of Ly6C(+) monocyte phenotypes in a mouse model with lipopolysaccharide (LPS)-induced ALI. Conditional SOCS3… CONTINUE READING