Lack of Reelin causes malpositioning of nigral dopaminergic neurons: Evidence from comparison of normal and Relnrl mutant mice

@article{Nishikawa2003LackOR,
  title={Lack of Reelin causes malpositioning of nigral dopaminergic neurons: Evidence from comparison of normal and Relnrl mutant mice},
  author={Shigeyuki Nishikawa and Satoshi Goto and Kazumichi Yamada and Tadashi Hamasaki and Yukitaka Ushio},
  journal={Journal of Comparative Neurology},
  year={2003},
  volume={461}
}
The reeler gene (Relnrl, formerly rl) product Reelin controls neuronal migration and positioning and thereby plays a key role in brain development. Mutation of Reln leads to widespread disruption of laminar cortical regions and ectopia in some brainstem nuclei. In the embryonic striatum of normal mice, a substantial expression of reelin mRNA has been documented; however, the anomalous positioning of neurons in the basal ganglia of reeler mice remains to be studied. We provide first evidence for… Expand
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