Lack of Predictivity of the Rat Lethality (LD50) Test for Ecological and Human Health Effects

@article{Rosenkranz2005LackOP,
  title={Lack of Predictivity of the Rat Lethality (LD50) Test for Ecological and Human Health Effects},
  author={Herbert S. Rosenkranz and Albert R. Cunningham},
  journal={Alternatives to Laboratory Animals},
  year={2005},
  volume={33},
  pages={19 - 9}
}
The relationship between acute toxicity in rats (LD50 values) and indicators of potential health hazards in humans was investigated, based on a chemical population-based paradigm (i.e. the “chemical diversity approach”). These structure–activity relationship-based analyses indicate that high toxicity in rats (i.e. a low LD50 value) is not a good predictor of health effects in humans. In fact, it was found that high acute toxicity to minnows, as well as toxicity to cultured cells, showed… 
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