Lack of Pharmacokinetic Drug-Drug Interaction between Orlistat and Cerivastatin

@article{Mck2000LackOP,
  title={Lack of Pharmacokinetic Drug-Drug Interaction between Orlistat and Cerivastatin},
  author={Wolfgang M{\"u}ck and Holger-Georg Adelmann and Thorsten Ruf and Sigrun Linger and Barbara Voith},
  journal={Clinical Drug Investigation},
  year={2000},
  volume={19},
  pages={71-73}
}
Cerivastatin is a novel, potent hydroxy-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitor that effectively reduces serum cholesterol levels at low daily doses.[1-3] Following almost complete absorption (>98%), cerivastatin is primarily cleared via biotransformation (hydroxylation leads to metabolite M-23, demethylation results in metabolite M-1) and subsequent biliary/ renal excretion of these active metabolites.[4] In contrast, the antiobesity drug orlistat acts to reduce fat absorption… CONTINUE READING