Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection

@inproceedings{Abdullah2012LackOP,
  title={Lack of PPARγ in Myeloid Cells Confers Resistance to Listeria monocytogenes Infection},
  author={Zeinab F. Abdullah and Sergej Geiger and Andrea C. Nino-Castro and Jan B{\"o}ttcher and Eugenia Muraliv and Moritz M. Gaidt and Frank A Schildberg and Kati Riethausen and Juliane Flossdorf and Wolfgang Krebs and Trinad Chakraborty and Christian Kurts and Joachim L. Schultze and Percy A Knolle and Luisa Klotz},
  booktitle={PloS one},
  year={2012}
}
The peroxisomal proliferator-activated receptor γ (PPARγ) is a nuclear receptor that controls inflammation and immunity. Innate immune defense against bacterial infection appears to be compromised by PPARγ. The relevance of PPARγ in myeloid cells, that organize anti-bacterial immunity, for the outcome of immune responses against intracellular bacteria such as Listeria monocytogenes in vivo is unknown. We found that Listeria monocytogenes infection of macrophages rapidly led to increased… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

The macrophage paradox.

View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Immunity to Listeria infection.

Current opinion in immunology • 2000
View 11 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…