Lack of Overt Genome Reduction in the Bryostatin-Producing Bryozoan Symbiont "Candidatus Endobugula sertula".

@article{Miller2016LackOO,
  title={Lack of Overt Genome Reduction in the Bryostatin-Producing Bryozoan Symbiont "Candidatus Endobugula sertula".},
  author={Ian J. Miller and Niti Vanee and Stephen S. Fong and Grace E. Lim-Fong and Jason C Kwan},
  journal={Applied and environmental microbiology},
  year={2016},
  volume={82 22},
  pages={6573-6583}
}
The uncultured bacterial symbiont "Candidatus Endobugula sertula" is known to produce cytotoxic compounds called bryostatins, which protect the larvae of its host, Bugula neritina The symbiont has never been successfully cultured, and it was thought that its genome might be significantly reduced. Here, we took a shotgun metagenomics and metatranscriptomics approach to assemble and characterize the genome of "Ca Endobugula sertula." We found that it had specific metabolic deficiencies in the… CONTINUE READING
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