Lack of Interference by Heparin With Thrombolysis or Binding of Tissue-Type Plasminogen Activator to Thrombi

Abstract

Coronary thrombolysis with t-PA is generally implemented with concomitant administration of heparin. However, results of studies in vitro suggest that heparin competes with fibrin for binding of tissue-type plasminogen activator (t-PA). augments activation of free plasminogen. decreases fibrin specificity. and impairs thrombolysis. To define the biological… (More)

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