Lack of Influence of Collagen Type Iα1 Sp1 Binding Site Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Danish Women Followed for 18 Years

@article{Heegaard2000LackOI,
  title={Lack of Influence of Collagen Type Iα1 Sp1 Binding Site Polymorphism on the Rate of Bone Loss in a Cohort of Postmenopausal Danish Women Followed for 18 Years},
  author={A. M. Heegaard and Henrik L\ovendahl J\orgensen and A. W. Vestergaard and Christian Hassager and Stuart H. Ralston},
  journal={Calcified Tissue International},
  year={2000},
  volume={66},
  pages={409-413}
}
A polymorphism in an Sp1 site in the collagen Iα1 (COLIA1) gene has recently been identified and the Ss and ss genotypes were shown to be potentially important determinants of low bone mass in postmenopausal women. Additionally, in a Dutch population, the association of the COLIA1 polymorphism with low bone mineral density (BMD) was more pronounced with increasing age, suggesting a genotype effect on the rate of bone loss. We have investigated the relationship between the COLIA1 Sp1… CONTINUE READING

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