Lack of IL-12 signaling in human allergen-specific Th2 cells.

@article{Hilkens1996LackOI,
  title={Lack of IL-12 signaling in human allergen-specific Th2 cells.},
  author={Catharien M. U. Hilkens and Gerald Messer and Kiki Tesselaar and A G van Rietschoten and Martien L. Kapsenberg and Eddy A. Wierenga},
  journal={Journal of immunology},
  year={1996},
  volume={157 10},
  pages={4316-21}
}
IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells. In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells. To this aim, allergen-specific CD4+ T cell clones (TCC) were generated from the peripheral blood of three atopic patients, and their cytokine profiles were analyzed. The majority of these TCC… CONTINUE READING
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