Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma.

@article{Chan2010LackOH,
  title={Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma.},
  author={Owen Chan and Zong-Ming Chen and Fai Chung and Kevin Kawachi and Dan C Phan and Eric A Himmelfarb and Fan Lin and Arie Perry and Hanlin L. Wang},
  journal={American journal of clinical pathology},
  year={2010},
  volume={134 6},
  pages={880-5}
}
HER2 overexpression and amplification have been studied as a therapeutic and prognostic target in a number of human cancers, including esophageal, gastric, and colorectal adenocarcinomas. However, HER2 status has not been well investigated in primary small intestinal adenocarcinoma, probably because of its rarity. In this study, we conducted immunohistochemical analysis and fluorescence in situ hybridization (FISH) for HER2 on 49 primary nonampullar small intestinal adenocarcinomas. The results… CONTINUE READING