Lack of Galectin-3 Drives Response to Paracoccidioides brasiliensis toward a Th2-Biased Immunity

@article{Ruas2009LackOG,
  title={Lack of Galectin-3 Drives Response to Paracoccidioides brasiliensis toward a Th2-Biased Immunity},
  author={Luciana Pereira Ruas and Emerson Soares Bernardes and Marise Lopes Fermino and Leandro Licursi de Oliveira and Daniel K. Hsu and Fu-tong Liu and Roger Chammas and Maria-Cristina Roque-Barreira},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={89 - 117}
}
There is recent evidence that galectin-3 participates in immunity to infections, mostly by tuning cytokine production. We studied the balance of Th1/Th2 responses to P. brasiliensis experimental infection in the absence of galectin-3. The intermediate resistance to the fungal infection presented by C57BL/6 mice, associated with the development of a mixed type of immunity, was replaced with susceptibility to infection and a Th2-polarized immune response, in galectin-3-deficient (gal3(-/-)) mice… CONTINUE READING

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Toxoplasma gondii infection reveals a dual role for galectin-3 on innate and adaptive immune response

ES Bernardes, NM Silva, LP Ruas, AM Loyola, DK Hsu
  • Am J Pathol
  • 2006
VIEW 3 EXCERPTS