Lack of Estrogen Receptor-a Is Associated with Epithelial – Mesenchymal Transition and PI 3 K Alterations in Endometrial Carcinoma

Purpose:We hypothesized that estrogen receptor-a (ER-a) status in endometrial carcinomas, associated with poor prognosis, is reflected in transcriptional signatures suggesting targets for new therapy. Experimental Design: Endometrial carcinoma samples in a primary investigation cohort (n 1⁄4 76) and three independent validation cohorts (n 1⁄4 155/286/111… (More)