Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.

@article{Tresini2001LackOE,
  title={Lack of Elk-1 phosphorylation and dysregulation of the extracellular regulated kinase signaling pathway in senescent human fibroblast.},
  author={Maria Tresini and Antonello Lorenzini and Lorenza Frisoni and Robert G. Allen and Vincent J. Cristofalo},
  journal={Experimental cell research},
  year={2001},
  volume={269 2},
  pages={287-300}
}
Replicative senescence is characterized by numerous phenotypic alterations including the loss of proliferative capacity in response to mitogens and numerous changes in gene expression including impaired serum inducibility of the immediate-early genes c-fos and erg-1. Transcription of c-fos in response to mitogens depends on the activation of a multiprotein complex formed on the c-fos serum response element (SRE), which includes the transcription factors SRF (serum response factor) and TCF… CONTINUE READING

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