Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes

@article{Blohm2002LackOE,
  title={Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes},
  author={U. Blohm and E. Roth and Kathrin Brommer and T. Dumrese and F. Rosenthal and H. Pircher},
  journal={The Journal of Immunology},
  year={2002},
  volume={169},
  pages={5522 - 5530}
}
Tumor-specific CD8 T cell responses to MCA102 fibrosarcoma cells expressing the cytotoxic T cell epitope gp33 from lymphocytic choriomeningitis virus were studied. MCA102gp33 tumors grew progressively in C57BL/6 mice, despite induction of peripheral gp33-tetramer+ T cells that were capable of mediating antiviral protection, specific cell rejection, and concomitant tumor immunity. MCA102gp33 tumors were infiltrated with a high number (∼20%) of CD11b+CD11c− macrophage-phenotype cells that were… Expand
Suppression of T cell responses in the tumor microenvironment.
  • A. Frey
  • Biology, Medicine
  • Vaccine
  • 2015
Concepts and ways to amplify the antitumor immune response.
  • B. Rubin, J. Gairin
  • Biology, Medicine
  • Current topics in microbiology and immunology
  • 2011
Antigen Cross-Presentation by Macrophages
PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 45 REFERENCES
A reversible functional defect of CD8+ T lymphocytes involving loss of tetramer labeling
Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection
  • J. Exp. Med
  • 2002
Antiviral Cd8+ T Cell Responses in Neonatal Mice
Cutting Edge: Lipid Raft Integrity Affects the Efficiency of MHC Class I Tetramer Binding and Cell Surface TCR Arrangement on CD8+ T Cells1
  • D. Drake, Thomas J. Braciale
  • Biology, Medicine
  • The Journal of Immunology
  • 2001
Discrepancy between ELISPOT IFN-γ secretion and binding of A2/peptide multimers to TCR reveals interclonal dissociation of CTL effector function from TCR-peptide/MHC complexes half-life
  • Verena Rubio-Godoy, Valerie Dutoit, +7 authors Danila Valmori
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Immunity against solid tumors?
Malignant glioma biology: Role for TGF‐β in growth, motility, angiogenesis, and immune escape
  • Michael Platten, Wolfgang Wick, Michael Weller
  • Biology, Medicine
  • Microscopy research and technique
  • 2001
Role of TGF‐β in immune‐evasion of cancer
...
1
2
3
4
5
...