Lack of Effect of Chronic Antidepressant Treatment on Gs and Gi α-Subunit Protein and mRNA Levels in the Rat Cerebral Cortex

Experimental evidence indicates that chronic antidepressant treatment in rats modifies the central nervous system β-adrenoceptor signaling pathway at multiple sites including receptor, G-protein, adenylyl cyclase, and protein kinase A. In the present study, we examined the postreceptor effect of antidepressant treatment on the protein and mRNA levels of… CONTINUE READING