Lack of Cross-Sensitization of the Locomotor Effects of Morphine in Amphetamine-Treated Rats

@article{Vanderschuren1999LackOC,
  title={Lack of Cross-Sensitization of the Locomotor Effects of Morphine in Amphetamine-Treated Rats},
  author={Louk J. M. J. Vanderschuren and Anton N M Schoffelmeer and Arie H. Mulder and Taco J. de Vries},
  journal={Neuropsychopharmacology},
  year={1999},
  volume={21},
  pages={550-559}
}
Repeated exposure to morphine and amphetamine induces long-lasting sensitization of their psychomotor stimulant properties, whereas pretreatment with morphine causes cross-sensitization of the locomotor effects of amphetamine. Here, we investigated whether pre-exposure to amphetamine also results in cross-sensitization to morphine. Rats pretreated with amphetamine (5 × 2.5 mg/kg, i.p.) displayed neither short-term (3 days post-treatment) nor long-term (3 weeks post-treatment) cross… CONTINUE READING