Corpus ID: 14941752

Lack of Commensal Flora in H. pylori–Infected INS-GAS Mice Reduces Gastritis and Delays Intraepithelial Neoplasia

@inproceedings{Lofgren2010LackOC,
  title={Lack of Commensal Flora in H. pylori–Infected INS-GAS Mice Reduces Gastritis and Delays Intraepithelial Neoplasia},
  author={J. Lofgren and M. Whary and Z. Ge and S. Muthupalani and N. Taylor and Melissa W. Mobley and A. Potter and A. Varr{\'o} and D. Eibach and S. Suerbaum and T. Wang and J. Fox},
  year={2010}
}
Background & Aims—Transgenic, insulin–gastrin (INS–GAS) mice have high circulating levels of gastrin. On a FVB/N background, these mice develop spontaneous atrophic gastritis and gastrointestinal intraepithelial neoplasia (GIN) with 80% prevalence 6 months after Helicobacter pylori infection. GIN is associated with gastric atrophy and achlorhydria, predisposing mice to non-helicobacter microbiota overgrowth. We determined if germ-free INS–GAS mice spontaneously develop GIN and if H. pylori… Expand

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