Lack of CYP3A4 inhibition by grapefruit juice and ketoconazole upon clozapine administration in vivo.

@article{Lane2001LackOC,
  title={Lack of CYP3A4 inhibition by grapefruit juice and ketoconazole upon clozapine administration in vivo.},
  author={Hannah Lane and Chi Chia Chiu and Yusuf R Kazmi and Himanshu Harshadrai Desai and Yarn. Lam and Michael W. Jann and Woo Hyuck Chang},
  journal={Drug metabolism and drug interactions},
  year={2001},
  volume={18 3-4},
  pages={
          263-78
        }
}
The drug-food and drug-drug interaction between grapefruit juice (GFJ) and ketoconazole (KETO) was evaluated in schizophrenic patients given a single dose of clozapine (CLZ). CLZ is metabolized primarily by CYP isozymes 3A4 and 1A2 to two principal metabolites, desmethylclozapine (DCLZ) and clozapine N-oxide (CNO). GFJ and KETO are well known potent CYP 3A4 inhibitors in the gastrointestinal tract and hepatic isozymes, respectively. Twenty-one schizophrenic patients participated in the co… CONTINUE READING
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