Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter (PIV) of CIITA.

@article{Elsen2000LackOC,
  title={Lack of CIITA expression is central to the absence of antigen presentation functions of trophoblast cells and is caused by methylation of the IFN-gamma inducible promoter (PIV) of CIITA.},
  author={Peter J. van den Elsen and Nienke van der Stoep and H E Vi{\"e}tor and Lisa C Wilson and Moniek van Zutphen and Sam J. P. Gobin},
  journal={Human immunology},
  year={2000},
  volume={61 9},
  pages={850-62}
}
Lack of MHC-mediated antigen presenting functions of fetal trophoblast cells is an important mechanism to evade maternal immune recognition. In this study we demonstrated that the deficiency in MHC expression and antigen presentation in the trophoblast cell lines JEG-3 and JAR is caused by lack of class II transactivator (CIITA) expression due to hypermethylation of its interferon-gamma (IFN-gamma)-responsive promoter (PIV). Circumvention of this lack of CIITA expression by introduction of… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
26 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…