Lack of CD28 expression on HIV-specific cytotoxic T lymphocytes is associated with disease progression.

@article{Gamberg2004LackOC,
  title={Lack of CD28 expression on HIV-specific cytotoxic T lymphocytes is associated with disease progression.},
  author={Jane Gamberg and Ingrid Pardoe and M. Ian Bowmer and Constance M Howley and M. Grant},
  journal={Immunology and cell biology},
  year={2004},
  volume={82 1},
  pages={
          38-46
        }
}
During HIV infection, CD8+ T cells lacking the costimulatory molecule CD28 increase in number and proportion. This accumulation is associated with disease activity and possibly with CD8+ T-cell dysfunction. In this study, CD8+CD28+ and CD8+CD28- T cells from 41 HIV-infected individuals at various stages of disease were compared in terms of HIV-specific cytotoxicity, TCR beta V repertoire diversity, and cytokine production. We found that the CD28 phenotype of anti-HIV CTL evolves in parallel… CONTINUE READING

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