Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus.

@article{Sakata2014LackOB,
  title={Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus.},
  author={Kazuko Sakata and Sean M Duke},
  journal={Neuroscience},
  year={2014},
  volume={260},
  pages={265-75}
}
Brain-derived neurotrophic factor (BDNF) is implicated in the pathophysiology of psychiatric conditions including major depression and schizophrenia. Mice lacking activity-driven BDNF expression through promoter IV (knock-in promoter IV: KIV) exhibit depression-like behavior, inflexible learning, and impaired response inhibition. Monoamine systems (serotonin, dopamine, and noradrenaline) are suggested to be involved in depression and schizophrenia since many of the current antidepressants and… CONTINUE READING

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