Lack of Association of Common Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations with Primary Sclerosing Cholangitis

@article{GallegosOrozco2005LackOA,
  title={Lack of Association of Common Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations with Primary Sclerosing Cholangitis},
  author={Juan Fernando Gallegos-Orozco and Catherine E. Yurk and Nulang Wang and Jorge Rakela and Michael R. Charlton and Garry R. Cutting and Vijayan Balan},
  journal={The American Journal of Gastroenterology},
  year={2005},
  volume={100},
  pages={874-878}
}
BACKGROUND:Primary sclerosing cholangitis (PSC) is a chronic progressive cholestatic liver disease of uncertain etiology. However, the histologic features of PSC liver disease can resemble those in cystic fibrosis (CF), an inherited disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. We sought to determine if PSC patients have a higher frequency of common CF alleles than disease controls.METHODS:DNA was extracted from peripheral lymphocytes of patients with… CONTINUE READING