Lack of Apaf-1 expression confers resistance to cytochrome c-driven apoptosis in cardiomyocytes

  title={Lack of Apaf-1 expression confers resistance to cytochrome c-driven apoptosis in cardiomyocytes},
  author={Daniel Sanchis and Marta Mayorga and Manel Ballester and Joan X Comella},
  journal={Cell Death and Differentiation},
AbstractApoptosis plays a role in cardiomyocyte death in several cardiovascular disorders. Here, we show that primary postnatal cardiomyocytes did not die upon activation of the intrinsic (cytochrome c-dependent) apoptotic pathway. Release of cytochrome c from mitochondria to the cytosol occurred, but did not activate the effector phase of apoptosis. Myocardial cells did not express apoptotic protease-activating factor-1 (Apaf-1), the allosteric activator of caspase-9 acting downstream of… CONTINUE READING
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