Lack of Apaf-1 expression confers resistance to cytochrome c-driven apoptosis in cardiomyocytes

@article{Sanchis2003LackOA,
  title={Lack of Apaf-1 expression confers resistance to cytochrome c-driven apoptosis in cardiomyocytes},
  author={Daniel Sanchis and Marta Mayorga and Manel Ballester and Joan X Comella},
  journal={Cell Death and Differentiation},
  year={2003},
  volume={10},
  pages={977-986}
}
AbstractApoptosis plays a role in cardiomyocyte death in several cardiovascular disorders. Here, we show that primary postnatal cardiomyocytes did not die upon activation of the intrinsic (cytochrome c-dependent) apoptotic pathway. Release of cytochrome c from mitochondria to the cytosol occurred, but did not activate the effector phase of apoptosis. Myocardial cells did not express apoptotic protease-activating factor-1 (Apaf-1), the allosteric activator of caspase-9 acting downstream of… CONTINUE READING
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: potential role of angiotensin II

  • P Anversa, A Leri, J Kajstura, B Nadal-Ginard
  • 2002

Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart . J . Mol . Cell . Cardiol

  • RJ Scheubel, B Bartling, +4 authors J Holtz
  • 2002

Differential expression of apoptotic protease - activating factor - 1 and caspase - 3 genes and susceptibility to apoptosis during brain development and after traumatic brain injury

  • N Joza, G Kroemer, JM Penninger
  • J . Neurosci .
  • 2002

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