Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice.

@article{FernandezBarrena2012LackOA,
  title={Lack of Abcc3 expression impairs bile-acid induced liver growth and delays hepatic regeneration after partial hepatectomy in mice.},
  author={Maite G Fernandez-Barrena and Mar{\'i}a Jes{\'u}s Monte and Mar{\'i}a Ujue Latasa and I. R. Uriarte and Eva Miedes Vicente and Haisul C. Y. Chang and Carlos M. Rodr{\'i}guez-Ortigosa and Ronald Oude Elferink and Carmen Berasain and Jose J G Marin and Jes{\'u}s Prieto and Matias A Avila},
  journal={Journal of hepatology},
  year={2012},
  volume={56 2},
  pages={
          367-73
        }
}
BACKGROUND & AIMS Bile acids (BA) are increasingly recognized as important modulators of liver regeneration. Increased enterohepatic BA flux has been proposed to generate specific signals that activate hepatocyte proliferation after partial hepatectomy (PH). We have investigated the role of the BA membrane transporter Mrp3 (Abcc3), which is expressed in the liver and gut, in the hepatic growth response elicited by BA and in liver regeneration after PH. METHODS Liver growth and regeneration… CONTINUE READING
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