Lacidipine: a review of its use in the management of hypertension.

@article{McCormack2003LacidipineAR,
  title={Lacidipine: a review of its use in the management of hypertension.},
  author={Paul L. McCormack and Antona J. Wagstaff},
  journal={Drugs},
  year={2003},
  volume={63 21},
  pages={
          2327-56
        }
}
UNLABELLED Lacidipine (Caldine, Lacimen, Lacipil, Midotens, Motens) is a once-daily, orally-administered, lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity, resulting in a lack of reflex tachycardia. It has a long duration of action and a high degree of vascular selectivity. In addition to calcium channel-modulated vasodilation, lacidipine displays antioxidant activity greater than that of other dihydropyridine calcium antagonists. In randomised, well… 

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References

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The Impact of Lacidipine, a Novel Dihydropyridine Calcium Antagonist, on Carbohydrate and Lipid Metabolism

It is concluded that lacidipine is a safe and effective drug in the long-term antihypertensive treatment of patients with essential hypertension and with concomitant metabolic disorders such as diabetes mellitus or dyslipidemia.

Effect of lacidipine on blood pressure, vasoactive hormones, and haemorheology in elderly patients with essential hypertension

Investigating the affects of lacidipine on the activity of the reninangiotensin-aldosterone system, plasma levels of natriuretic peptides and haemorheological profile in elderly patients with essential hypertension found it desirable that a calcium antagonist has a gradual onset and long duration of action and causes minimal activation of counterregulatory systems.

Efficacy and Safety of Lacidipine, a New Long‐Lasting Calcium Antagonist, in Elderly Hypertensive Patients

4 mg once daily is an effective and well-tolerated antihypertensive treatment in the elderly and, as with the general adult population, represents the optimal long-term maintenance dose.

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The efficacy and tolerable of lacidipine (a calcium) blocker of the dihydropyridine class and hydrochlorothiazide (a diuretic) were compared in a 12 week double-blind randomised parallel group study of Nigerians with essential hypertension.

Effect of lacidipine, a dihydropyridine calcium antagonist on renal function of hypertensive patients with renal insufficiency.

It is suggested that renal function should be monitored closely in patients with renal insufficiency when a calcium antagonist is being used to control blood pressure, particularly in those with either marginal blood pressure control, significant albuminuria or an incipient nephrotic syndrome.

Pharmacology of Lacidipine, a Vascular‐Selective Calcium Antagonist

The marked vascular selectivity of lacidipine was clearly evident both in pithed rats infused with angiotensin II and in anesthetized dogs, in which preferential and long-lasting coronary and vertebral blood flow increases were also observed.

An assessment of lacidipine and atenolol in mild to moderate hypertension.

Assessment of the interaction between the new calcium antagonist, lacidipine and atenolol, in patients with mild to moderate hypertension found that exercise tolerance was not adversely affected and co-administration of both drugs produced a significant additive effect.

Clinical Pharmacology of Lacidipine

Two specialized electrophysiologic studies in patients confirmed that lacidipine does not affect pacemaker tissue and that it exhibits relative selectivity for the vascular smooth muscle, and its pharmacodynamic and pharmacokinetic profiles evaluated.

Safety aspects of treatment with lacidipine--a slow-onset, long-acting calcium antagonist.

Lidipine is found to be an effective and well tolerated drug with a reasonable adverse profile typical for a calcium antagonist of the dihydropyridine group, and a lower fatal event rate than previously reported in the actively treated hypertensives in Collins' meta-analyses.

A Long‐Term Study Comparing Lacidipine and Nifedipine SR in Hypertensive Patients: Safety Data

Lacidipine can be considered a safe antihypertensive drug, which can be used as a suitable agent for first‐line treatment of hypertension.
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