Laboratory to community: chemoprevention is the answer.

@article{Olden2014LaboratoryTC,
  title={Laboratory to community: chemoprevention is the answer.},
  author={Kenneth Olden and Suryanarayana V Vulimiri},
  journal={Cancer prevention research},
  year={2014},
  volume={7 7},
  pages={648-52}
}
In the current issue, Johnson and colleagues present exciting results, using biomarkers involved in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis, as an example of a conceptual framework to target mechanisms of action in developing chemopreventive agents. Their innovative approach offers considerable promise for a field that has long been neglected. Proof-of-principle was demonstrated using a synthetic triterpenoid (CDDO-Im), which activates Nrf2 signal transduction pathway, inhibits… CONTINUE READING

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Showing 1-10 of 28 references

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.

Toxicological sciences : an official journal of the Society of Toxicology • 2011
View 2 Excerpts

Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 1 Excerpt

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