Laboratory to community: chemoprevention is the answer.

  title={Laboratory to community: chemoprevention is the answer.},
  author={Kenneth Olden and Suryanarayana V Vulimiri},
  journal={Cancer prevention research},
  volume={7 7},
In the current issue, Johnson and colleagues present exciting results, using biomarkers involved in aflatoxin B1 (AFB1)-induced hepatocarcinogenesis, as an example of a conceptual framework to target mechanisms of action in developing chemopreventive agents. Their innovative approach offers considerable promise for a field that has long been neglected. Proof-of-principle was demonstrated using a synthetic triterpenoid (CDDO-Im), which activates Nrf2 signal transduction pathway, inhibits… CONTINUE READING

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Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.

Toxicological sciences : an official journal of the Society of Toxicology • 2011
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Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

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