Laboratory to Community: Chemoprevention Is the Answer

  title={Laboratory to Community: Chemoprevention Is the Answer},
  author={K. Olden and S. V. Vulimiri},
  journal={Cancer Prevention Research},
  pages={648 - 652}
  • K. Olden, S. V. Vulimiri
  • Published 2014
  • Medicine
  • Cancer Prevention Research
  • In the current issue, Johnson and colleagues present exciting results, using biomarkers involved in aflatoxin B1 (AFB1)–induced hepatocarcinogenesis, as an example of a conceptual framework to target mechanisms of action in developing chemopreventive agents. Their innovative approach offers considerable promise for a field that has long been neglected. Proof-of-principle was demonstrated using a synthetic triterpenoid (CDDO-Im), which activates Nrf2 signal transduction pathway, inhibits… CONTINUE READING
    8 Citations

    Topics from this paper.

    Retrospective and Prospective Look at Aflatoxin Research and Development from a Practical Standpoint
    • N. Benkerroum
    • Business, Medicine
    • International journal of environmental research and public health
    • 2019
    • 4
    • PDF
    Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.
    • 18
    • PDF


    Dietary Aflatoxin Exposure and Chemoprevention of Cancer: A Clinical Review
    • D. Sudakin
    • Chemistry, Medicine
    • Journal of toxicology. Clinical toxicology
    • 2003
    • 73
    • PDF
    Complete Protection against Aflatoxin B1-Induced Liver Cancer with a Triterpenoid: DNA Adduct Dosimetry, Molecular Signature, and Genotoxicity Threshold
    • 57
    • Highly Influential
    • PDF
    Chemoprevention of cancer.
    • 557
    From carcinogenesis to clinical interventions for cancer prevention.
    • 32
    Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes
    • 241
    • PDF
    Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk.
    • 84
    Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.
    • 444
    • PDF
    Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
    • 540
    Molecular dosimetry of aflatoxin DNA adducts in humans and experimental rat models.
    • 13