Laboratory tests for defining bactericidal activity as predictors of antibiotic efficacy in the treatment of endocarditis due to Staphylococcus aureus in rabbits.

@article{Fass1984LaboratoryTF,
  title={Laboratory tests for defining bactericidal activity as predictors of antibiotic efficacy in the treatment of endocarditis due to Staphylococcus aureus in rabbits.},
  author={Robert J. Fass},
  journal={The Journal of infectious diseases},
  year={1984},
  volume={149 6},
  pages={
          904-12
        }
}
The validity of laboratory tests that define bactericidal activity to predict antimicrobial efficacy was studied in rabbits with endocarditis due to Staphylococcus aureus, both nafcillin-nontolerant (NT) and nafcillin-tolerant (T). Infected rabbits were treated with nafcillin, clindamycin, chloramphenicol, or no drug (control) for up to 11 days; dosage was designed so that peak antibiotic serum concentration/minimal inhibitory concentration ratios were approximately 50. During treatment, peak… CONTINUE READING
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