Laboratory reproducibility of biochemical markers of bone turnover in clinical practice

@inproceedings{Schafer2009LaboratoryRO,
  title={Laboratory reproducibility of biochemical markers of bone turnover in clinical practice},
  author={Anne L. Schafer and Eric Vittinghoff and Rageshree Ramachandran and Norouz Mahmoudi and Doug Bauer},
  booktitle={Osteoporosis International},
  year={2009}
}
To determine the laboratory reproducibility of urine N-telopeptide and serum bone-specific alkaline phosphatase measurements, we sent identical specimens to six US commercial labs over an 8-month period. Longitudinal and within-run laboratory reproducibility varied substantially. Efforts to improve the reproducibility of these tests are needed. We assessed the laboratory reproducibility of urine N-telopeptide (NTX) and serum bone-specific alkaline phosphatase (BAP). Serum and urine were… CONTINUE READING

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