Laboratory properties of cold-adapted influenza B live vaccine strains developed in the US and USSR, and their B/Ann Arbor/1/86 cold-adapted reassortant vaccine candidates.

@article{Alexandrova1990LaboratoryPO,
  title={Laboratory properties of cold-adapted influenza B live vaccine strains developed in the US and USSR, and their B/Ann Arbor/1/86 cold-adapted reassortant vaccine candidates.},
  author={Galina I. Alexandrova and Hunein F. Maassab and Alan P. Kendal and T E Medvedeva and Andrei Y. Egorov and Alexander I. Klimov and Nancy J. Cox},
  journal={Vaccine},
  year={1990},
  volume={8 1},
  pages={61-4}
}
The adaptation of two influenza B strains (B/Leningrad/14/55 and B/Ann Arbor/1/66) to replication at 25 degrees C is described. Comparison of the two viruses indicates that both also exhibit temperature sensitive phenotypes, although that of the virus B/Leningrad/14/55 is less pronounced. When inoculated into ferrets both viruses replicate well in the trachea, but only the B/Leningrad/14/55 cold-adapted virus replicates in the lungs. This virus exhibited a moderate level of attenuation in the… CONTINUE READING

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