Laboratory methods to detect antiphospholipid antibodies.

  title={Laboratory methods to detect antiphospholipid antibodies.},
  author={Steven Antony Krilis and Bill Giannakopoulos},
  journal={Hematology. American Society of Hematology. Education Program},
  volume={2014 1},
This chapter reviews several important themes pertaining to the antiphospholipid syndrome (APS), including a description of the clinical features, a discussion of the main autoantigen, beta 2-glycoprotein I (β2GPI), and insights into the characteristics of the pathogenic anti-β2GPI autoantibodies. Evidence-based considerations for when to test for APS are explored, along with the clinical significance of patients testing positive on multiple APS assays, so-called triple positivity. A detailed… CONTINUE READING