Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways.


The first and highly conserved step in glutathione (GSH) biosynthesis is formation of γ-glutamyl cysteine by the enzyme glutamate-cysteine ligase (GshA). However, bioinformatic analysis revealed that many prokaryotic species that encode GSH-dependent proteins lack the gene for this enzyme. To understand how bacteria cope without gshA, we isolated… (More)
DOI: 10.1038/nchembio.499

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