Laboratory diagnosis of toxigenic Clostridium difficile by polymerase chain reaction: presence of toxin genes and their stable expression in toxigenic isolates from Japanese individuals

@article{Karasawa1999LaboratoryDO,
  title={Laboratory diagnosis of toxigenic Clostridium difficile by polymerase chain reaction: presence of toxin genes and their stable expression in toxigenic isolates from Japanese individuals},
  author={Tadahiro Karasawa and Takashi Nojiri and Yasuhiro Hayashi and Tsuneo Maegawa and Kiyotaka Yamakawa and Xing M. Wang and Shinichi Nakamura},
  journal={Journal of Gastroenterology},
  year={1999},
  volume={34},
  pages={41-45}
}
Abstract:Clostridium difficile causes pseudomembranous colitis and antibiotic-associated diarrhea. The definitive diagnosis of C. difficile infection is finally accomplished by the isolation of toxigenic C. difficile. However, only a small number of Japanese clinical laboratories are able to reach a definitive diagnosis of C. difficile infection, probably because simple reliable assays for toxins in the isolates are not available. In this study, we examined the compatibility of a polymerase… CONTINUE READING

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