Laboratory assessment of vitamin K status

  title={Laboratory assessment of vitamin K status},
  author={D. Card and R. G{\'o}rska and D. Harrington},
  journal={Journal of Clinical Pathology},
  pages={70 - 75}
Vitamin K is required for the ɣ-carboxylation of specific glutamic acid residues within the Gla domain of the 17 vitamin K-dependent proteins (VKDPs). The timely detection and correction of vitamin K deficiency can protect against bleeding. Vitamin K also plays a role in bone metabolism and vascular calcification. Patients at increased risk of vitamin K deficiency include those with a restricted diet or malnutrition, lipid malabsorption, cancer, renal disease, neonates and the elderly… Expand
Vitamin K and Osteoporosis
It is pointed out the relevance of an adequate vitamin K intake to obtain sufficient levels of carboxylated (active form) vitamin K dependent proteins (such as Osteocalcin and matrix Gla protein) to prevent bone health. Expand
Current Therapy in CKD Patients Can Affect Vitamin K Status
It is hypothesized that vitamin K deficiency is the common pathogenetic link between impaired bone mineralization and vascular calcification in CKD patients. Expand
Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis
The importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system during the COVID-19 crisis is highlighted. Expand
Micronutrient Status of Recreational Runners with Vegetarian or Non-Vegetarian Dietary Patterns
It is suggested that a well-planned, health-conscious lacto-ovo-vegetarian and vegan diet, including supplements, can meet the athlete’s requirements of vitamin B12, vitamin D and iron. Expand
Thrombin Generation in Preterm Newborns With Intestinal Failure-Associated Liver Disease
Despite prolonged PTs and aPTTs infants with IFALD had similar ETP than those without, and cholestatic patients had a lower birthweight, longer exposure to PN, and longer hospitalization. Expand
British Obesity and Metabolic Surgery Society Guidelines on perioperative and postoperative biochemical monitoring and micronutrient replacement for patients undergoing bariatric surgery—2020 update
  • M. O’Kane, H. Parretti, +14 authors J. Barth
  • Medicine
  • Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2020
These guidelines are comprehensive, encompassing preoperative and postoperative biochemical monitoring, vitamin and mineral supplementation and correction of nutrition deficiencies before, and following bariatric surgery, and make recommendations for safe clinical practice in the U.K. setting. Expand


Vitamin K: dietary intake and requirements in different clinical conditions
With the increased incidence of vitamin K-deficient bleeding and weight-loss surgical procedures, healthcare professionals need to monitor vitamin K status in certain patient populations. Expand
Vitamin K and human nutrition.
  • J. Suttie
  • Chemistry, Medicine
  • Journal of the American Dietetic Association
  • 1992
A Recommended Dietary Allowance of 1 micrograms/kg body weight has been established for vitamin K and advances in analytic techniques and more sensitive clotting factor assays will make it possible to define the human requirement for this vitamin more accurately. Expand
Vitamin K nutrition and osteoporosis.
This review summarizes current knowledge regarding a possible role of vitamin K insufficiency in the pathogenesis of osteoporosis and investigates whether vitamin K indirectly affects the skeleton via control of renal calcium excretion. Expand
The role of vitamin K in soft-tissue calcification.
This study showed maintenance of vascular elasticity during a 3-y supplementation period, with a parallel 12% loss of elasticity in the placebo group, and new conformation-specific assays for circulating uncarboxylated MGP were developed; an assay for desphospho-uncarboxylation matrix Gla protein and another assay for total uncar boxylated matrix GlA protein. Expand
Vitamin K status of healthy Japanese women: age-related vitamin K requirement for gamma-carboxylation of osteocalcin.
If submaximal gamma-carboxylation is related to the prevention of fracture or bone mineral loss, circulating vitamin K concentrations in elderly people should be kept higher than those in young people. Expand
Vitamin K nutrition, metabolism, and requirements: current concepts and future research.
There is still a lack of suitable biomarkers or clinical endpoints that can be used to determine vitamin K requirements among adults, and there is a need for stable isotope studies with enhanced sensitivity to expand knowledge of the bioavailability, absorption, disposition, and metabolism of different molecular forms of vitamin K. Expand
Vitamin K-dependent coagulation factors deficiency.
The following review will summarize the clinical manifestations of vitamin K-dependent coagulation factors deficiency I and II and will provide a detailed explanation about the gene and protein structure, the function of the protein, and an analysis of the previously reported mutations. Expand
The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis.
The preponderance of the evidence suggests that bacterially synthesized menaquinones, particularly in the ileum can and do play a significant role in contributing to vitamin K requirements in humans to prevent clinically significant coagulopathy, especially during periods of episodic dietary lack of the vitamin. Expand
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
  • J. McCann, B. Ames
  • Biology, Medicine
  • The American journal of clinical nutrition
  • 2009
A triage perspective reinforces recommendations of some experts that much of the population and warfarin/coumadin patients may not receive sufficient vitamin K for optimal function of VKD proteins that are important to maintain long-term health. Expand
The view that vitamin K given prophylactically at birth will help to prevent neonatal bleeding is supported and PIVKA-II levels might be more useful than a coagulation test. Expand