Laboratory Contributions to the Tobacco-cancer Problem*

@article{Wynder1959LaboratoryCT,
  title={Laboratory Contributions to the Tobacco-cancer Problem*},
  author={Ernest L. Wynder},
  journal={British Medical Journal},
  year={1959},
  volume={1},
  pages={317 - 322}
}
  • E. Wynder
  • Published 7 February 1959
  • Medicine
  • British Medical Journal
The sum total of evidence linking smoking to cancer of the respiratory tract is based upon different types of evidence: presumptive, epidemiological, pathological, animal, and chemical. All of the evidence so far established demonstrates smoking to be a carcinogenic factr.TFis niiow ourtasikto bring, the problem posed 6y-this association to a successful solution. The present report represents an evaluation of the contributions that laboratory research is making in this field. The importance of… 

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chemical analyses of the tar did not disclose the basis for the higher carcinogenic activity of the Colombian tobacco tar and the differences in mortality between Cali and the United States and Europe are apparently due to differences in the smoking pattern of the two populations.

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A striking increase in abnormal intracellular RNA agglomerations, associated with absence of mitosis and cell destruction, preceded the atypical proliferations of other cells in the respiratory tract in mice exposed to influenza virus alone, or in combination with cigarette smoke.

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