Laboratory Contributions to the Tobacco-cancer Problem*

  title={Laboratory Contributions to the Tobacco-cancer Problem*},
  author={Ernest L. Wynder},
  journal={British Medical Journal},
  pages={317 - 322}
  • E. Wynder
  • Published 7 February 1959
  • Medicine
  • British Medical Journal
The sum total of evidence linking smoking to cancer of the respiratory tract is based upon different types of evidence: presumptive, epidemiological, pathological, animal, and chemical. All of the evidence so far established demonstrates smoking to be a carcinogenic factr.TFis niiow ourtasikto bring, the problem posed 6y-this association to a successful solution. The present report represents an evaluation of the contributions that laboratory research is making in this field. The importance of… 

Tobacco habits in carcinoma of the upper respiratory tract.

Clinical evidence and recent research strongly suggests that the use of tobacco is important in the etiology of cancer of the respiratory and oral mucosa and several chemical constituents are responsible.

Tobacco toxicology revisited.

  • H. Witschi
  • Medicine, Political Science
    Advances in experimental medicine and biology
  • 2001
In the Western World aggressive campaigning and education against tobacco use by both private interest groups and government agencies have slowed down, if not decreased, the incidence of lung cancer, the most lethal disease.

The Effects of Dietary Myoinositol on Lung Tumor Development in Tobacco Smoke-Exposed Mice

It was concluded that myoinositol has less chemopreventive activity against the full complex mixture of tobacco smoke than it has against selected constituents such as NNK or benzo[a]pyrene.

The carcinogenic potential of the gas phase of environmental tobacco smoke.

The gas phase of ETS is as carcinogenic as is full ETS and the carcinogenicity of the gas phase may be due to some as yet unidentified, yet highly potent carcinogens or by placing a substantial, possibly free radical-mediated oxidative stress on the lung.

Comparative carcinogenic effect of two types of tobacco

chemical analyses of the tar did not disclose the basis for the higher carcinogenic activity of the Colombian tobacco tar and the differences in mortality between Cali and the United States and Europe are apparently due to differences in the smoking pattern of the two populations.

The Composition of Cigarette Smoke. An Historical Perspective of Several Polycyclic Aromatic Hydrocarbons

Abstract Because of the significant advancements in fractionation, analytical, and characterization technologies since the early 1960s, hundreds of components of complex mixtures have been accurately

Cytological and cytochemical alterations in the respiratory tract of mice after exposure to cigarette smoke, influenza virus, and both.

A striking increase in abnormal intracellular RNA agglomerations, associated with absence of mitosis and cell destruction, preceded the atypical proliferations of other cells in the respiratory tract in mice exposed to influenza virus alone, or in combination with cigarette smoke.


Management commences with the diagnosis of pregnancy, when the mother's Rh group must be determined, and inquiry should be made as to whether the mother has been pregnant before, or whether she has received a transfusion or an injection of blood at any time in her life.

Large-scale fractionation of cigarette smoke condensate for chemical and biologic investigations.

Cigarette smoke condensate was separated into acidic, basic, and neutral fractions which were further divided into 12 subfractions by procedures designed to yield adequate amounts for bioassay of all



Reader's Digest, July

  • Oncologia (Basel),
  • 1958

Acta path. microbiol. scand

  • 1955

Acda palh. microbiol. scand

  • 1957

A Study of Tobacco Carcinogenesis . VII . The Higher Aromatic Polycyclics