Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation.

@article{Ho2004LabileZA,
  title={Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation.},
  author={Lien Ha Ho and Richard E. Ruffin and Chiara Murgia and Lixin Li and Steven Antony Krilis and Peter David Zalewski},
  journal={Journal of immunology},
  year={2004},
  volume={172 12},
  pages={7750-60}
}
The granules of mast cells and other inflammatory cells are known to be rich in zinc (Zn), a potent caspase inhibitor. The functions of granular Zn, its mechanism of uptake, and its relationship to caspase activation in apoptosis are unclear. The granules of a variety of mast cell types fluoresced intensely with the Zn-specific fluorophore Zinquin, and fluorescence was quenched by functional depletion of Zn using a membrane-permeable Zn chelator N, N, N', N'-tetrakis (2-pyridyl-methyl… CONTINUE READING
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