Corpus ID: 46830227

Labile aggregation stimulating substance, free fatty acids, and platelet aggregation.

@article{Gerrard1976LabileAS,
  title={Labile aggregation stimulating substance, free fatty acids, and platelet aggregation.},
  author={Jonathan M. Gerrard and J. G. White and William Krivit},
  journal={The Journal of laboratory and clinical medicine},
  year={1976},
  volume={87 1},
  pages={
          73-82
        }
}
Labile aggregation stimulating substance (LASS), an intermediate produced during platelet biosynthesis of PGE2 and PGF2alpha, acts as a physiologic intercellular messenger to promote platelet aggregation and the release reaction. The activity is formed by intact cells after physiologic stimulation or can be generated from platelet membrane fractions after combination with arachidonate. In the present investigation, small amounts of polyunsaturated fatty acids added to an incubation mixture of… Expand
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