Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates.


Aptamers that bind to prostate specific membrane antigen (PSMA) were conjugated to luminescent CdSe and CdTe nanocrystals for cell-labeling studies. The aptamer-nanocrystal conjugates showed specific targeting of both fixed and live cells that overexpressed PSMA. More importantly, aptamers were able to label cells dispersed in a collagen gel matrix simulating tissue. The specific binding abilities and synthetic accessibility of aptamers combined with the photostability and small size of semiconductor nanocrystals offers a powerful and general tool for cellular imaging.

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@article{Chu2006LabelingTC, title={Labeling tumor cells with fluorescent nanocrystal-aptamer bioconjugates.}, author={Ted Chu and F. H. Shieh and Laura A. Lavery and Matthew Levy and Rebecca R. Richards-Kortum and Brian A Korgel and Andrew D. Ellington}, journal={Biosensors & bioelectronics}, year={2006}, volume={21 10}, pages={1859-66} }