Labeling TiO2 nanoparticles with dyes for optical fluorescence microscopy and determination of TiO2-DNA nanoconjugate stability.

@article{Thurn2009LabelingTN,
  title={Labeling TiO2 nanoparticles with dyes for optical fluorescence microscopy and determination of TiO2-DNA nanoconjugate stability.},
  author={Kenneth T. Thurn and Tatjana Paunesku and Aiguo Wu and Eric M B Brown and Barry Lai and Stefan Vogt and Joerg Maser and Mohammed Aslam and Vinayak Dravid and Raymond C. Bergan and Gayle E. Woloschak},
  journal={Small},
  year={2009},
  volume={5 11},
  pages={1318-25}
}
Visualization of nanoparticles without intrinsic optical fluorescence properties is a significant problem when performing intracellular studies. Such is the case with titanium dioxide (TiO2) nanoparticles. These nanoparticles, when electronically linked to single-stranded DNA oligonucleotides, have been proposed to be used both as gene knockout devices and as possible tumor imaging agents. By interacting with complementary target sequences in living cells, these photoinducible TiO2-DNA… CONTINUE READING
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