Labeled antigens and antibodies: the evolution of magic markers and magic bullets

@article{Silverstein2004LabeledAA,
  title={Labeled antigens and antibodies: the evolution of magic markers and magic bullets},
  author={A. M. Silverstein},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={1211-1217}
}
The ability to label antigens and antibodies with simple chemicals and even with whole proteins fostered new approaches to basic studies of the immune system as well as new methods of immunodiagnosis and immunotherapy. This was especially true following the introduction of monoclonal antibodies, which enhanced the specificity of many of these applications. The uses to which these labeled immunoreagents were put were legion, and those who employed them might come from any field of biology or… 

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