Label-free quantitative proteomics of rat hypothalamus under fever induced by LPS and PGE2.

@article{Firmino2018LabelfreeQP,
  title={Label-free quantitative proteomics of rat hypothalamus under fever induced by LPS and PGE2.},
  author={Marina Firmino and S. Weis and Jaques M F Souza and Bruna R. B. Gomes and A. R. M{\'o}l and M. Mortari and G. Souza and G. C. Coca and T. Williams and W. Fontes and C. Ricart and M. V. de Sousa and F. H. Veiga-Souza},
  journal={Journal of proteomics},
  year={2018},
  volume={187},
  pages={
          182-199
        }
}
Fever is a brain-mediated increase in body temperature mainly during inflammatory or infectious challenges. Although there is considerable data regarding the inflammation pathways involved in fever, metabolic alterations necessary to orchestrate the complex inflammatory response are not totally understood. We performed proteomic analysis of rat hypothalamus using label-free LC-MS/MS in a model of fever induced by lipopolysaccharide (LPS) or prostaglandin E2 (PGE2). In total, 7021 proteins were… Expand
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