Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip.

@article{Hsu2009LabelfreeQO,
  title={Label-free quantification of asymmetric cancer-cell filopodium activities in a multi-gradient chip.},
  author={T H Hsu and Meng-Hua Yen and W. Liao and Ji-Yen Cheng and Chau-Hwang Lee},
  journal={Lab on a chip},
  year={2009},
  volume={9 7},
  pages={884-90}
}
We use novel super-resolution bright-field optical microscopy to observe the filopodium activities of human lung cancer cells in a multi-gradient cell culture chip. Temporal variations of the filopodium numbers are measured without fluorescent labelling. By carefully designing the fluidic field inside the culture chip, we establish stable concentration… CONTINUE READING