Label-free quantification of Tacrolimus in biological samples by atomic force microscopy.

Abstract

In the present paper we describe an atomic force microscopy (AFM)-based method for the quantitative analysis of FK506 (Tacrolimus) in whole blood (WB) samples. Current reference methods used to quantify this immunosuppressive drug are based on mass spectrometry. In addition, an immunoenzymatic assay (ELISA) has been developed and is widely used in clinic… (More)
DOI: 10.1016/j.aca.2015.05.014

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